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The mitragynine-induced CB 1 receptor upregulations appeared to be attenuated by NIDA-41020 as seen in the immunohistochemical, protein, and mRNA studies

The proposed mechanism includes a peptide-induced support of -AR gene transcription, potentially leading to increased mRNA expression and receptor density on adipocyte membranes

The pain usually follows one nerve territory on one side of the body, such as the chest wall, abdomen, face, arm, or leg