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These mouse models emphasize the dependency of NF1-associated optic pathway glioma on timing of NF1 inactivation, cell-of-origin, and on the tumor microenvironment as NF1 heterozygosity was required for optic glioma formation

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Stimulation of NMDARs (75) induces iron deposition in cells by activating the GTP (guanosine triphosphate) -binding protein Dexrasl, which contributes to activate the metal ion transporters, including the divalent metal transporter-1 (DMT1) (76) found that intravitreal injection of NMDA led to Fe 2+ accumulation in RGCs and triggered their apoptosis, resulting in a lower number of cells 7 days after injection

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