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Structural analogs with changes in functional group at sn -2 position have previously been shown to lack different PAF C-16 associated activities such as aggregation of platelets (McManus et al., 1981), NO production from endothelial cells (Kikuchi et al., 2008), excitation of synaptic transmission in neuronal cells ( PAF C-18, a naturally occurring PAF C-16 analog, was also used to investigate the effect of increase in the number of carbon atoms in the aliphatic carbon tail on the intracellular M

Zukor, K

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This long-lasting epigenetic modification implies that short-term early interventions (e.g., targeted inhibition of DNMT1 or ROS scavenging) could potentially reverse or normalize the trained immune phenotype of BMMs, thereby exerting long-term benefits for bone health by interrupting the inflammation-bone resorption vicious cycle

Recent reports suggest a significant association between CDI and metabolic liver diseases