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The reticulocyte proportion was 4.17%, with a reticulocyte count of 0.1093 x 10^12/L, and peripheral blood showed anisocytosis and abnormal morphology, with evidence of compensatory hyperplasia in the bone marrow

Additionally, glutathione status has been investigated for its role in tumor necrosis factor- induced activation of NF-B, which demonstrated that NF-B activation is related to cellular glutathione levels[21]

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From the data presented, it can be concluded that energy metabolism requires appropriate intracellular levels of BH4 to support bioenergetic processes that are independent of those catalyzed by BH4 as an enzyme cofactor