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Description

By binding to melanocortin receptors, particularly MC1R, Melanotan I enhances pigmentation, provides UV protection, and reduces the risk of sunburn

Cells, 13(18), 1545.

Furthermore, -KG triggered metabolic reprogramming to an M2 gene expression profile by promoting JMJD3-dependent histone demethylation in the promoter of M2 marker genes (Liu et al., 2017)