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Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes

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Oxidative stress-induced chondrocyte death is a critical event during the development of OA, and existing researchers have identified apoptosis and necrosis as forms of chondrocyte death [28]

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