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Summary FOXO4-DRI is a pioneering senolytic peptide designed to selectively target and eliminate senescent cellsthose that have lost their ability to divide yet persist in a pro-inflammatory, dysfunctional state

These contractile cells play a crucial role in regulating blood flow and glomerular filtration rate by adjusting capillary diameter

80 Next, firm adhesion is mediated through, for example, the macrophage antigen-1 (Mac-1/CD11b) expressed on neutrophils and its ligand ICAM-1 expressed on the endothelium

Kuchibhotla KV, Wegmann S, Kopeikina KJ et al (2014) Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

Sofic E, Lange KW, Jellinger K, Riederer P