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For sham surgery, the mice underwent the same procedure without vessel occlusion

ghrelin mimetics have a core peptide backbone with differing lengths of the backbone (tri-, tetra-, penta-, and hexapeptides, as well as macrocyclic)

Using a genome-wide screen, we identify aldolase A, a key glycolytic enzyme that converts fructose-1,6-bisphosphate (FBP), as a regulatory switch that links metabolic flux to FA assembly and cell morphogenesis

Specifically, the substitutions at the 2nd, 15th, and 27th positions may help the peptide resist being broken down by enzymes and extend its half-life

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