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Retrospective analysis revealed that this was driven by a direct redox reaction between the manganese-based mimetic and the platinum-based chemotherapy (oxaliplatin) when administered in close proximity [317, 318]

Growing evidence suggests that the gut microbiota not only regulates host metabolism and immunity, but also communicates with the reproductive endocrine system through modulation of estrogen metabolism 116,187

Adding high-performance exosomes, growth factors, or stem cells could create a single treatment for chemotherapy-induced ovarian insufficiency, thin endometrium, and implantation failure

Histopathological examination and immunofluorescence staining The dorsal skin was preserved in 10% buffered formalin for a duration of 24 h before being embedded in paraffin wax

Concurrently, they suppress CYP2E1 activity, limiting acetaldehyde-induced ROS generation, and inhibit TLR4/MyD88 signaling to reduce TNF- and IL-6 secretion (Nagappan et al., 2019