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10.1016/j.celrep.2016.09.056 Cell Rep

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Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state

Furthermore, a two-way ANOVA results revealed a nonsignificant change in GABA levels in the midbrain, thalamus and hypothalamus, and hippocampus between the duration of IF and the diet regimen intervention ( F = 2.873, p = 0.076), ( F = 2.216, p = 0.131), and ( F = 0.848, p = 0.441), respectively

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