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Studies show it may be well tolerated in higher doses of 700mg three times a day, as well, with few to no adverse effects when taken as an oral supplement (but we dont recommend taking more than what a supplement manufacturer instructs).31 That's not to say that adverse effects aren't out of the question

[85] Effectiveness is generally expected to slowly decrease over time

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Thioctic acid can be injected directly into a vein using a syringe and perfusor, even with a minimum injection time of 12 minutes

Some experts believe that the absolute minimum amount of stored vitamin B12 should be 500 g