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Clinical observations on individuals with pernicious anaemia suggests that intra-muscular treatment with high-dose vitamin B12 over a period of a few weeks typically resolves the neurological symptoms in most cases [9, 10], suggesting a reversible biochemical state, and not an irreversible degeneration or loss as seen in some forms of dementia

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This is generally related to the caloric deficit rather than the medication itself, and it typically resolves as caloric intake stabilizes

Comparison to other compound dosing For context, the dosing requirements of 5-amino-1mq differ significantly from traditional peptides