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The downstream effects include: Synaptogenesis : Formation of new synaptic connections in hippocampal neurons, driven by c-Met-mediated activation of PI3K/AKT and MAPK/ERK signaling cascades Spinogenesis : Growth of new dendritic spines, the structural substrate for excitatory synaptic transmission Neurotrophic support : In cell-based neurotrophic assays, Dihexa demonstrated potency approximately seven orders of magnitude greater than BDNF The HGF/c-Met pathway is distinct from the BDNF/TrkB and NGF/TrkA pathways targeted by most nootropic peptides

Epithalon has been shown to restore thymus function and support T-cell maturation in aging subjects, effectively recalibrating immune surveillance toward a more youthful functional profile

Cancer 11 , 644656 (2011)

(12(4)) doi:10.3390/children12040442

plantarum has been shown to protect intestinal epithelial barrier function from ETEC K88 infection in NCM460 cells derived from normal human colon mucosal epithelium