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It can also affect liver function, which plays a role in hormone metabolism

Paul BT, Manz DH, Torti FM, Torti SV (2017) Mitochondria and iron: current questions

The biological plausibility of this argument derives from well-characterized phenomena, including donor-age-related MSC senescence, reduced paracrine secretory capacity, and diminished immunomodulatory potency, that have been demonstrated in cell culture and animal models