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But, the growing number of patients with no or low response to PDE5I, and the potential of adverse reactions have prompted the development of safer and more effective treatments ( Figure 1 Drug therapy: Phosphodiesterase 5 inhibitors Phosphodiesterase 5 (PDE5) is highly expressed in vascular smooth muscle and it is the most common PDE subtype in penile smooth muscle

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Arslan H, Aksu D, Terz GLel G, Nisbet C

When heavy metals are mobilized in the organism during concussion therapy, they can temporarily increase their concentration in the blood before being eliminated, creating a toxic load that could worsen symptoms in the short term and potentially interfere with other aspects of concussion rehabilitation

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