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Graphical abstract First-line biologic therapy selection highly impacts ulcerative colitis outcomes: results from the APPETISER study Table 1

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It is also reported that the qnr gene originates from the chromosomes of many aquatic bacteria and can compete with other qnr proteins from other sources, which can inhibit the entry of quinolones into the cleavage complex, reduce double-strand breaks on chromosomes, and reduce the chromosome toxicity of quinolones

Clinical study participants Forty-five subjects were screened for the trial and 44 (48% females) were enrolled (1 screening failure due to higher BMI, see Figure 3) between March and July 2023