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Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

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doi: 10.1186/s40104-022-00715-1 3 GaoYZhaoSZhangYZhangQ

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TNF- impairs insulin signaling by activating JNK1 and NF-B pathways, contributing to insulin resistance, a hallmark of PCOS 216,217,218

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