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Aleem E, Nehrbass D, Klimek F, et al

Phytotherapy in diabetes: review on potential mechanistic perspectives

Metabolic & Performance Testing Advanced diagnostic testing to measure how your body functions and build a personalized plan for performance, weight loss, and long term health

found that circRNA-SORE, upregulated in sorafenib-resistant HCC cells, hindered the degradation of Y-box-binding protein 1 (YBX1) by E3 ubiquitin ligase processing factor 19 (PRP19) and prevented nuclear translocation of the carcinogenic protein YBX1

In doing so, CAFs act as metabolic support hubs, promoting a ferroptosis-resistant ecosystem that facilitates tumor survival under oxidative and nutrient-deprived conditions (Xiao et al., 2024)