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In the original healthy-adult study of albumin-binding CJC-1295, single subcutaneous doses raised mean plasma GH 2- to 10-fold for six days or more and mean IGF-I 1.5- to 3-fold for nine to eleven days, with an estimated elimination half-life on the order of roughly six to eight days a pharmacokinetic profile measured in days , not minutes

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IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [9]

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Rather than introducing growth hormone directly, as synthetic HGH does, sermorelin signals the pituitary gland to release more of the body's own growth hormone, in the body's normal pulsatile pattern