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In: Frymoyer JW (ed) The adult spine: principles and practice

This kind of trial is expensive typically several million dollars and to date has been more difficult to justify economically because GHK-Cu cannot be patented as a novel drug (the molecule is endogenous and the relevant patents have expired)

Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

Most patients require multiple sessions, typically four to six treatments, spaced four to six weeks apart

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