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References: Pieren, D

Vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), and basic fibroblast growth factor (bFGF) are highly expressed in various tumors and are considered important signal transducers in angiogenesis, involving the MAPK (Mitogen-Activated Protein Kinase), PI3K (Phosphoinositide 3-kinase)/Akt, and other signaling pathways (Sui et al., 2014)

The work of Ryan and colleagues supported this view and proposed the mechanism of drug resistance in which wild-type RAS, which could not be specifically inhibited by KRAS (G12C) inhibitors, rapidly activated the adaptive KRAS feedback pathway mediated by PTK after ARS-1620 and AMG510 treatment in vitro 170

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The model was first fitted to the training concentrations (37.5 and 25 M doxorubicin), and then used to simulate the test concentrations (50, 12.5 and 10 M doxorubicin) as a means of blind validation, showing good accordance between the experimental and in silico outputs for all concentrations of doxorubicin