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Abbreviations Abu: -Aminobutyric acid ACC: 7-Amino-4-carbamoylmethylcoumarin DCM: Dichloromethane DMF: Dimethylformamide Et 3 N: Triethylamine HMPTA: Hexamethylphosphoramide MeCN: Acetonitrile Py-FLINT: Pyrene-based fluorescence intensity SAM: S -Adenosyl-l-methionine THF: Tetrahydrofuran Tle: tert -Leucine References Wang, C

Advanced phase 1 studies provide additional information on the drug candidates pharmacological effects, metabolism, adverse effects linked to dose escalation, and potentially early effectiveness data

Characteristics of the included studies In total, 20 studies were selected after meeting the inclusion criteria, including ten animal studies and nine human studies

Macrophages control the bioavailability of vitamin D and vitamin D-regulated T cell responses

40 Core Molecular Mechanisms of Lactylation The process of protein lactylation is precisely regulated by a set of key enzymes that operate according to established enzymatic principles