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Lineu Prestes, 748, Cidade Universitria, So Paulo 05508-000, Brazil [email protected] This article was submitted to Chemical Biology, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The mechanisms involved in GABA release were first investigated in beta cell lines, where GABA secretion was shown to be dependent on the presence of extracellular Ca 2+ [105], suggesting that GABA is released in response to an increase in cytosolic Ca 2+ levels

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