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The FDA and CDC have both documented cases of counterfeit or misused botulinum toxin products causing serious harm in the United States

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The same issue extends to AGD measurements, where it is critical that measurement are performed the same way for each animal to avoid technical variations that could obscure subtle changes between study groups

The prodrugs consisted of three domains, a ROS acceptor that can be sensitive to ROS, an effector that is the native drug part, and a linker between the ROS acceptor and the effector

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