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doi: 10.1038/s41591-019-0522-3 201 PaiJAHellmannMDSauterJLMattarMRizviHWooHJet al

Adenosine is known to play a role in pain transmission, and its deficiency may exacerbate pain symptoms in FM patients (Fais et al., 2013)

201,202 Administration of the PRMT6 inhibitor EPZO20411 can inhibit the arginine methylation of chromatin condensation regulator 1 (RCC1), block the tyrosine kinase 2 (CK2) -PRMT6-RCC1 signaling axis, inhibit the proliferation of glioblastoma stem cells (GSCs) and increase their sensitivity to radiotherapy

PMID: 22015471

It has also been reported that astrocytes orchestrate responses to cerebral inflammatory diseases, impaired glymphatic function, and other types of CNS injury (Salman et al., 2022)