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Bioavailability and BloodBrain Barrier Penetration A critical challenge in translating neuroprotective compounds into effective therapies is their bioavailability and ability to cross the bloodbrain barrier (BBB)

Meanwhile, CIH may affect cytokine levels in the TME, such as tumor necrosis factor- (TNF-), interleukin-8 (IL-8), and interleukin-6 (IL-6), through the activation of NF-B (Li et al., 2011)

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Further exploration found that ISA could lower the plasma levels of IL-6 and TNF-, which are also closely associated with depression (Wang et al., 2023

In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation (Metha et al