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Supplementation (with very conservative doses) may be beneficial for those carrying the risk T allele of C667T or the risk C allele of A1298C

introduction of two random mutations of Y444A and G484A to D433N resulted in up to 50-fold increase in catalytic efficiency for GL-7-ACA substrate (Yamada et al., 2008)

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Thus, designing the lumen with longitudinally-oriented channels associated with aligned NFs would mimic the bands of Bngner where Schwann cells (SCs) form aligned bands between damaged nerve ends to guide axons [5, 9]

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