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We discuss both cuprizone-induced oligodendrocyte-intrinsic mechanisms of demyelination and oligodendrocyte-extrinsic factors that can induce or exacerbate oligodendrocyte toxicity, with a focus on extrinsic immune-derived factors

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We note that, as discussed in the FY 2025 IPPS/LTCH PPS final rule (89 FR 69109), the current MS-DRG relative weight methodology does not include MA cases as discharges for Medicare beneficiaries enrolled in a MA managed care plan are excluded from the relative weight methodology