alpha glutathione s transferase phase ii biomarker S-transferase Hypermethylation of the glutathione S-transferase

Principles of treatment The aim of treatment is to achieve a T4 level in the normal range a TSH level in the normal range AND The doses is primarily titrated to the TSH level The typical dose is 1.6g/Kg, but the dose should be started low and titrated up to this Typically this means doses are in the 100-200g per day range Initially give 25-50g, and review after 6 weeks Start at the lower end for frail and elderly patients Adjust the dose every 6 weeks so that TSH levels are in the normal range (not suppressed) Low TSH suggests over-replacement of T4 (even if T4 is not elevated) titrate the dose down until TSH returns to the normal range High TSH suggests under-replacement increase the dose of levothyroxine The half life of T4 is about 7 days, so any change in the dose will not be clinically noticeable for about 4 weeks

Clear therapeutic response: The dramatic improvement with B12 supplementation reinforces the diagnosis and therapeutic pathway

Krakow in numbers 2017

Glutathione present in the NC24 Sakura Glutathione injection 800000mg lightens visible sun damage, age spots, or scars

a reduction product, free APAP