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Deletions in CDKN2A (cyclin-dependent kinase inhibitor 2A) impair the cell cycle checkpoint, whereas aberrant activation of stem cell markers such as SRY-Box transcription factor 2 (SOX2) supports tumor cell self-renewal and invasion

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Pulmonary ILC2 isolation and ex vivo experiments Mice were intranasally challenged with 0.5 g of rmIL-33 (BioLegend) once per day for three days before tissue collection

Temko JE, Bouhlal S, Farokhnia M, Lee MR, Cryan JF, Leggio L

The descriptions of potential mechanisms are based on published research and are not guarantees of individual outcomes