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Third, blends that combine GHK-Cu with signal peptides such as Matrixyl-type ingredients aim for complementary pathways, though they make it harder to attribute results to copper alone

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Consistent with these findings, IF staining demonstrated that the nanocomposite treatment preserved COL2 expression and reduced MMP13 fluorescence intensity compared to the untreated group (Figure S21C)

Addolorato G, Stefanini GF, Capristo E, et al

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