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It is used for the treatment and prevention of hypokalemia with or without metabolic alkalosis when dietotherapy with potassium-rich foods or diuretic dose reduction present poor effect.

Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease

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Mutations in MCT8 cause AllanHerndonDudley syndrome, a devastating neurodevelopmental disorder characterized by profound cognitive and motor impairment (19, 54)