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Inflammatory pathways, including activation of NF-kB and release of pro-inflammatory cytokines, further exacerbate testicular damage and reduce sperm quality, as shown by Hasan et al [68]

In this highly heterogeneous context, the identification of recurrent biological features (i.e., biological endophenotypes) or recurrently affected pathways can be a key to understand the mechanisms underlying ASD

USA 117 , 1669016701 (2020)

Clinical trials have explored its use in mood disorders, depression, and post-traumatic stress disorder (PTSD)

Our findings enhance understanding of the genetic factors linked to sporadic VCI and provide new insights for managing its progression through targeted therapeutic interventions