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2 The gut-kidney axis: orchestrating the pathogenesis of CKD 2.1 Disrupted gut microbiota: a catalyst for CKD onset The perturbation of gut microbiota homeostasis has emerged as a pivotal orchestrator in the pathogenesis of CKD, manifesting through temporally-orchestrated microbial compositional metamorphoses characterized by the quintessential depletion of SCFA-producing commensals and the concomitant proliferation of opportunistic pathogens (Evenepoel et al., 2023

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