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As well as general chaperone activity, PDI family members possess oxidoreductase activity, which mediates the formation of protein disulfide bonds by cysteine residues located within its active site

Silymarin refers to the extract from the seeds of the plant Silybum marianum, also called milk thistle. It has been used for over 2,000 years

Obesity and diabetes are increasingly recognized as risk factors for PDAC, not only because of the remodelling of the tumour microenvironment but also because of their effects on systemic metabolism [249, 250]

Riluzole was the first FDA-approved compound for ALS (in 1995), which inhibits glutamatergic neurotransmission and thus inhibits excitotoxicity (Dharmadasa and Kiernan, 2018

Our findings show that early neuronal maturation is accompanied by increased mitochondrial content, enhanced respiratory capacity and function, a metabolic shift toward OXPHOS, and redirection of glucose-derived carbons toward biosynthetic and antioxidant pathways