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However, colchicine has been associated with neurological side effects, including cognitive impairment and memory loss, which can resemble symptoms seen in AD

Body weight increased 0.8 kg in the placebo group and 2.7 kg in the MK-677 group

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

Understanding the role of pathways such as the PPP, which expurgate excessive amounts of ROS, might be crucial for finding an effective treatment against PD

Balance is always more beneficial than excess