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Invest Ophthalmol Vis Sci 52 (2011): 8186-92

Liver (hepatic) and kidney safety considerations are equally important, since some supplements that undergo hepatic metabolism or renal excretion can accumulate or interact with chemotherapeutic drugs leading to hepatotoxicity (e.g., kava, high-dose green tea extract) or nephrotoxicity in patients who already suffer from impaired organ function or taking chemotherapy agents known to be nephrotoxic such as cisplatin (208, 209)

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Some glutathione supplements contain magnesium stearate, stearic acid, rice-based fillers, or flow agents like NuFlow. While these additives may simplify manufacturing, they add no value to the consumer and, in some cases, may even hinder absorption