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Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation

Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

Thomas DA, Cortes J, OBrien S, Faderl S, Ravandi F, Garcia-Manero G, Giles F, Beran M, Koller C, Wierda W, Verstovsek S, Ferrajoli A, Kornblau S, Keating M, Andreeff M , Kantarjian H

The ovarian follicular reserve is swiftly diminished and prematurely activated in genetically modified mouse models when one or more components of this pathway are deliberately eliminated in the oocyte (Castrillon et al

Activated microglia, through the secretion of inflammatory cytokines like interferon- (IFN-), participate in inflammatory responses, affecting copper uptake and transport