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Daily intraperitoneal injection of VGB4 at different doses (0.25, 1, 2.5, 5 and 10 mg/kg) or scr (10 mg/kg) was administrated for treated groups whereas the control group received the equal volume of PBS for two weeks

doi: 10.1183/13993003.01891-2019 203

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However, further research is needed to evaluate the efficacy of these strategies in clinical settings

Recent human studies have highlighted presence of bioenergetic maladaptation in brains in aging and neurodegenerative disorders, including PD [4, 5]