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At the matrix level, abundant deposition of extracellular matrix (ECM) components and sustained activation of cancer-associated fibroblasts (CAFs) densify the stroma and create major physical barriers to the diffusion of nanoparticles and macromolecules [30, 32, 34]

Fact: Bioavailability is the limiting factor

We adapted our experiments to include DAPI labeling for nuclei when cellular localization of the protein needed to be considered, as example, to compare nuclear versus cytoplasmic protein levels (Fig

Das bedeutet, dass die Ergebnisse zwar vielversprechend sind, aber nicht automatisch in gleicher Strke auf jedes topische Hautpflegeprodukt bertragbar sind

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