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Patients should be counseled never to administer extra doses to make up for missed doses, as this could increase the risk of adverse effects without providing additional therapeutic benefit

Reactions were performed with 0.001 mg/ml DNA substrate Poly(dI-dC), 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human DNMT1 enzyme

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