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Hopefully, future clinical studies will be conducted on neuroprotective drugs reported in this review by utilizing physicochemical and pharmacokinetic properties of drugs to treat TBI and other CNS diseases

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For immunohistochemistry, detection was performed using a biotinylated anti-rabbit IgG secondary antibody and streptavidin-Horseradish peroxidase (HRP), followed by colorimetric detection using DAB

Other assessments included changes in laboratory parameters (including but not limited to haematology and biochemistry), and physical examination, vital signs and ECG

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