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The purine pathway, whose regulation seems to be connected to TRP metabolism, has also been implicated in depression and other psychiatric disorders 29

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Loss of mitochondrial complex III demonstrated that it is necessary for antigen-driven T cell activation and proliferation but dispensable for lymphopenia-induced homeostatic proliferation in vivo (14)

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Yang-Hartwich Y., Soteras M.G., Lin Z.P., Holmberg J., Sumi N., Craveiro V., Liang M., Romanoff E., Bingham J., Garofalo F., et al