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Good use cases include tendon irritation, ligament sprains, muscle strains, plantar fascia irritation, rotator cuff irritation, Achilles tendinopathy, patellar tendinopathy, tennis elbow, golfers elbow, and joint-adjacent soft-tissue pain

Similarly, women who are breastfeeding should avoid NAD+ injections, since it is unknown whether the exogenous NAD+ could affect the nursing infant or alter milk composition

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For patients who want to avoid surgery, or where surgery carries a higher risk due to age or comorbidities, pain can often be successfully controlled with an optimized combination of medications and outpatient interventional procedures (targeted nerve blocks, minimally invasive treatments that reduce nerve irritation)