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Animal models for neuropathic pain can be developed by peripheral nerve injury, induction with drugs, as a consequence of other disease models (e.g., diabetes, cancer, and neurodegeneration) or viral infection

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE

Gastroenterology 151 , 945960.e946 (2016)

This demonstrates that DHEA caused a systemic inflammatory response and activated local ovarian signaling pathways in the ovaries

drug concentrations may not adequately represent pharmacokinetics, perhaps leading to an overestimation of therapeutic benefits