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Tricyclic antidepressants, such as cyclobenzaprine are dosed at 520 mg or nortriptyline, initiated at a dose of 10 mg at bedtime, while SNRIs like duloxetine and venlafaxine are started at 30 mg and 37.5 mg daily, respectively, titrated to a maximum of 50% of that used in non-cirrhotic population

Similarly, other researchers have reported that, compared to insulin, metformin treatment better controls postprandial blood sugar during pregnancy reduces the risk of hypoglycemia, and limits maternal weight gain, thereby preventing the onset of GDM in pregnancies with PCOS (Picon-Cesar et al., 2021)