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These data support the hypothesis that ferroptosis contributes significantly to PVL pathogenesis, and modulation of oligodendrocyte ferroptosis represents a promising therapeutic target for future neuroprotective strategies

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Emerging research continues to reveal novel regulatory axes and crosstalk between ferroptosis and other cell death modalities

Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

Furthermore, by securing their metabolic resilience against ferroptosis, DJ-1-competent astrocytes can better provide trophic support, regulate extracellular glutamate, and mitigate neuroinflammatory cascades, all processes that indirectly influence neuronal susceptibility to ferroptotic death (Cao et al., 2020)