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The Seven Countries Studies by Ancel Keys showed that coronary heart disease (CHD) mortality rates were higher in countries with higher blood levels of cholesterol (e.g

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Indeed if ovariectomized animals were treated for 4 weeks with either oral 17-estradiol or raloxifene, endothelium-dependent relaxations to ADP were increased compared to ovariectomized animals but these relaxations were mediated by both NO and an inhibitory prostanoid only in veins from estradiol-treated animals