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Echocardiography was performed before, directly after and 5 h after intracardiac injection of B-017 (0.8 mg kg 1 BW in 50 l 0.9% NaCl) using a Vevo 2100 Imaging System (FUJIFILM VisualSonics, Inc.)

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Nitric oxide is synthesized by nitric oxide synthases (NOS) and plays vital roles in vascular regulation, neurotransmission, and immune responses [5, 30]

Better understanding of the mechanism and TGR/TrxR reduced species involved in the binding of inhibitors depending on microenvironment may offer an additional avenue to control inhibitor selectivity in organism, tissue, and cell type specific manner

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