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Epub 2023 Nov 12

Nonlinear regression of the STAND-protein binding data was performed using the HillLangmuir equation: B = B max [STAND protein]/[ K d + [STAND protein]] where B is the concentration of the STAND protein bound to the antigen, B max is the number of total binding sites, [STAND protein] is the free STAND concentration, and K d is the dissociation constant

Evidence shows that p53 downregulates SLC7A11 expression, blocking cystine uptake, impairing GPX4 activity, and promoting the intracellular accumulation of LPO, ultimately triggering ferroptosis